OPC 3    

"Oligomeric Proanthocyanidins"

Product info

Details

Isotonix OPC-3® is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine and pine bark extracts, and citrus extract bioflavonoids, all found to be powerful antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.* Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state. Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Benefits:

The most powerful antioxidant supplement on the market today! Provides complete antioxidant protection.

  • Promotes cardiovascular health PLUS:
    • Helps maintain healthy cholesterol and blood glucose levels
    • Helps maintain healthy circulation by strengthening capillaries, arteries and veins
    • Promotes healthy blood vessel dilation
  • Demonstrates anti-inflammatory activity and promotes joint health

Additional Benefits

  • Combats free radicals
  • Helps maintain joint flexibility
  • Helps reduce mild menstrual cramping and abdominal pain
  • Helps support visual health/visual acuity
  • Potent free radical scavenger
  • Promotes healthy blood vessel dilation
  • Promotes healthy nitric oxide levels
  • Supports a healthy complexion
  • Supports healthy blood glucose levels
  • Supports healthy platelet activity
  • Supports healthy sperm quality
  • Promotes sinus comfort
  • Supports immune health

Gluten Free - Vegetarian - No Detectable GMO - Pycnogenol

Ingredients

Grape Seed Extract (25 mg)
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.*

 

Red Wine Extract (25 mg)
Red wine extract is a powerful antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.*

 

In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.*

 

Pine Bark Extract (Pycnogenol®) (25 mg)
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.

 

The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels.*

 

As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.*

 

Bilberry Extract (25 mg)
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.*

 

Citrus Extract (Bioflavonoids) (25 mg)
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.*

 

Get More Info or Buy OPC3 

 

SCIENCE:

  • Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
  • Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994
  • Cesarone, M., et al. Improvement in Circulation and in Cardiovascular Risk Factors With a Proprietary Isotonic Bioflavanoid Formula OPC-3. Journal Angiology 59: 408-414, 2008.
  • Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
  • Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NYAcademy of Sciences 928: 141-156, 2001.
  • Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
  • Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
  • Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
  • Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
  • Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
  • Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
  • Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
  • Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
  • Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
  • Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
  • Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
  • Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
  • Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
  • Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
  • Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
  • Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
  • Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. , 2004.
  • Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
  • Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
  • Rohdewald, P. Pycnogenol®. In ""Flavonoids in Health and Disease"". Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
  • Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
  • Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
  • Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
  • Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
  • Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
  • Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
  • Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
  • Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
  • Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
  • Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
  • Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
  • Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
  • Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
  • Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
  • Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
  • Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
  • Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
  • Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
  • Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
  • Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
  • Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
  • Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
  • Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
  • Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
  • Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
  • Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
  • Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
  • Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
  • Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
  • Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
  • Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
  • Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
  • Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
  • Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
  • Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
  • Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
  • Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
  • Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
  • Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
  • Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
  • Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.
  • Lau B et al. Pycnogenol as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
  • Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
  • Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
  • Hosseini S, Pishnamazi S, Sadrzadeh MH, Farid F, Farid R, Watson RR. Pycnogenol® in the management of asthma. J Med Food 4: 201-209, 2001.
  • Cheshier, J.E et al. Immunomodulation by Pycnogenol® in retro-virus infected or ethanol-fed mice. Life Sci., 58(5): 87-96, 1996.
  • Park, Y.C., Rimbach, G., Saliou, C., Valacchi, G. and Packer, L. Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages. FEBS Letters, 465: 93-97, 2000.
  • Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  • Liu, F.J., Zhang, Y.X. and Lau B.H.S. Pycnogenol® enhances immune and haemopoietic functions in senescence-accelerated mice.CMLS, Cell.Mol. Life. Sci., 54: 1168-1172, 1998.

May we also recommend:

Order here:

Order Vitamin B Complex

 

What is Nutri-Physical® Nutritional Analysis?

Identifying areas of nutrition where you need extra supplementation is a difficult task. Harder still is wading through the vast assortment of vitamins and minerals that claim to improve your health and well-being. Maybe you have a rough idea of where to start, but why leave anything to chance?

That's why we developed Nutri-Physical Nutritional Analysis, a free tool that can help you chose the proper supplementation regimen based on your diet and lifestyle. The result of your Nutri-Physical are based on overall best fit derived from your answers to a detailed online questionnaire that takes into account diet and exercise, family history personal habits and more.

Unlike other health questionnaires, Nutri-Physical explores all aspects of your diet, lifestyle and fitness to make concrete recommendations. Plus, with a unique color coding system, you can easily identify which products are most important for your health.

Every three to four months, come back to Shop.com and retake Nutri-Physical to receive new supplement recommendations at no cost. It's easy, it's customizable and it's free - three great reasons to take your Nutri-Physical today!

How does Nutri-Physical work?

Nutri-Physical Nutritional Analysis was developed by a team of experts who designed a series of questions around major health-related conditions currently plaguing our nation. After taking the comprehensive questionnaire, your responses are analyzed, calculated, and ranked on a point system. Then, based on this analysis, a daily nutrition supplement regimen is suggested based on your area of highest need and which products best fit those needs.

You'll receive three options: one that includes individual supplement recommendations; a second that creates a personalized Nutri-Physical Custom Cocktail by Isotonix; and a third that includes both individual products and your Nutri-Physical Custom cocktail recommendation. You can decide to choose any of the three options, or customize your supplement order and purchase whatever products you choose.

What can Nutri-Physical do for me?

If you are new to supplementation, Nutri-Physical is an excellent resource for identifying areas of need in your current lifestyle that would benefit from nutritional supplementation. If you are already taking nutritional supplements, Nutri-Physical can serve to reinforce the use of those products or make recommended adjustments that would further optimize your efforts and maximize your desired results.

Nutri-Physical FAQ

Why should I take the Nutri-Physical?

Anyone who is looking to attain optimal health and vitality should take Nutri-Physical Nutritional Analysis. Learning about oneself is the key to maximizing these desired outcomes and Nutri-Physical does exactly that by utilizing your individual responses to specific health and lifestyle questions in several important categories.

How often should I take Nutri-Physical?

If one is looking seriously to obtain optimal health and vitality, taking the survey every 90 to 120 days should be sufficient.

What do I accomplish by taking Nutri-Physical every 90 to 120 days?

You will be able to track your improvements in deficiency percentages and make adjustments to your daily nutritional supplementation regimen.

What if I can not afford to implement the recommended nutritional supplementation regime?

First, look to evaluate each product recommended with its active ingredients and reference those active ingredients to food groups and specifically food types. Try to incorporate those foods into your daily diet.

Second, examine your commitment to reach optimal health and vitality, review your finances and become creative. Nutri-Physical lists its nutritional supplement recommendation according to your priorities determined from the product priorities which were based on your answers to the questions. Begin your program with one or two recommended products, if possible.

Should I consult my physician prior to starting a nutritional supplementation program?

Absolutely. Reaching optimal health and vitality means asking your health professional to identify any pre-existing conditions or to review the recommended nutritional supplements you wish to take and relate them to your current condition and any prescribed medication. Ask your Nutri-Physical Administrator for information on recommended nutritional products as well as the ingredients and nutritional facts. You can also click on the pictures of your recommended products for more information.

Click on the link to get started

http://ca.shop.com/THESHOPCONSULTANT/cc.class/cc?main=t&act=NutriPhysical&ccsyn=898&credituser=C1314540 

Ordering Product:

For Supplements for USA www.MaggiesVitaminsUSA.com

For Supplements for Canada www.MaggiesVitamins.ca

 

 

 

 

 

Life Coaching

 

Business Coaching

 

Social Media Coaching

 

I believe......

That life is meant to be meaningful, joyous, and happy. That we are creatures of love and empowerment. That we are here to design and create lives that not only "work" but that have meaning and fulfillment for ourselves and for those around us. That we can be the best that we can be if we so choose. … or that perhaps creating a life of "simple things" is what may better serve us. It is not what we create, but that we CAN create the ideal life for us. That balance in life and work not only IS attainable but can be fun and rewarding.

… Maggie

"The reason I chose Maggie is because she is so genuine and caring. I immediately felt at ease and comfortable speaking with her. I knew that my secrets were safe with her – the real me was safe with her. Her sense of humour didn’t hurt either! She’s pretty remarkable really.

I’ve always felt that I’m on my way to “something or somewhere” and feeling increasingly stressed out that I didn’t know what or where. I’m still not sure of the final destination, but now I know that I’m looking forward to the journey!"

.... Madge R

Connect With:

Connect@MaggieHolbik.com
807-627-1831

Sign Up

Sign up for tips, news, and updates.

© 2016 Webpros2