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Vitamin D

  • Promotes normal bone mineral density
  • Promotes healthy arteries 
  • Supports immune health 
  • Helps maintain bone health 
  • Helps maintain bone mass by supporting normal osteoclast activity
  • Helps maintain cardiovascular health 
  • Promotes elasticity of blood vessels 
  • Helps maintain normal blood pressure 
  • Women with low bone density have been found to be deficient in vitamin K

 

*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure or prevent any disease.

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Product Classification

 

Gluten-Free - the finished product contains no detectable gluten

Vegetarian - Isotonix OPC-3 is a vegetarian product

No Detectable GMO - the finished product contains no detectable genetically modified organisms

Isotonic-Capable Drinkable Supplements - easy-to-swallow supplements in liquid form are immediately available to the body for absorption.

 

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Why Choose Isotonix Vitamin D?

 

Isotonix Vitamin D with K2 contains vitamin D3, the metabolically active form of vitamin D, along with vitamin K2, a form of vitamin K which supports vascular health and calcium utilization. Vitamin D plays an important role in bone health, heart health and immune support while working with vitamin K to support normal absorption of calcium, and promote healthy arteries.

Isotonix Vitamin D is the first of its kind to deliver both of these powerful vitamins with isotonic delivery. Vitamin K is included in Isotonix Vitamin D with K2 because of its unique partnership with vitamin D. Vitamins K and D work together to support calcium absorption and utilization. Vitamin K supports the normal delivery of calcium to the bones and promotes healthy arteries. At least two naturally occurring forms of vitamin K have been identified and are known as K1 and K2. While there are many similarities between these two forms of vitamin K, they are distinguished by their important differences.

The most significant difference between K1 and K2 is their chemical structure, which results in different pharmacokinetic properties. Vitamin K1 is retained primarily in the liver where, at high doses, it may interfere with the action of warfarin and other anticoagulant medications. Vitamin K2 has a different mechanism of action. It is transported primarily to bones and blood vessels. Vitamin K2 helps to maintain bone mass, support calcium utilization and promote elasticity of blood vessels. Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications.*

However, most products containing vitamin K (including K1 and/or K2 ) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2 . Related terms: vitamin D, vitamin K, bone health, cardiovascular health, immune support, D3, K2

 

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Isotonix Delivery System

Isotonix - the World's Most Advanced Nutraceuticals
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream.With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

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Ingredients

 

Vitamin D3 (Cholecalciferol): 5000 IU 
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, primarily in the duodenum and jejunum by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth and bone remodeling by osteoblasts and osteoclasts.

Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns, and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s normal modulation of neuromuscular function and immune function. Vitamin D has been shown to support immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. In reference to cellular health, vitamin D supports the modulation of many genes that are responsible for encoding proteins that regulate normal cell cycle activity. Vitamin D levels have been strongly correlated to healthy cells. Lastly, through its interaction with VDR (vitamin D receptor), vitamin D supports the healthy expression of the gene encoding renin, thus helping to maintain healthy blood pressure.*

Vitamin K2: 45 mcg 
Vitamin K is a fat-soluble vitamin found meat, eggs, dairy and natto. Although a fat-soluble vitamin, the body stores very little K2, and its stores are rapidly depleted without regular dietary intake. Natural vitamin K2, also known as menaquinone-7 (MK-7), is the most bioavailable form of K2 and has the longest half-life in the blood of any form of vitamin K. The Japanese soy food natto is particularly rich in menaquinone-7 (MK-7). Studies of natto consumption in Japan have linked menaquinone-7 to bone and cardiovascular health. The correlation of vitamin K to cardiovascular and bone health directly focuses on supporting proper calcium utilization, whereby adequate metabolism of calcium supports arterial and bone health. This is often referred to as the calcium paradox.

The calcium paradox is explained simply as getting calcium in the right place (i.e., into the bone structures instead of the arterial vessel walls). These events are dependent upon the synthesis of the vitamin K-dependent proteins osteocalcin and matrix Gla protein in a process called carboxylation. The carboxylation of these proteins is a post-translational step; that is, osteocalcin and matrix Gla protein are translated from their respective messenger RNA and then modified by enzymes to the active forms. These carboxylated forms support the healthy binding and releasing of calcium. This reaction is essential for optimal and healthy utilization of calcium. Vitamin K2 promotes the synthesis of proteins involved with calcium utilization, thereby supporting bone retention and arterial health. While vitamin D supports the healthy regulation and synthesis of osteocalcin, the mineral-binding capacity of this protein requires vitamin K-dependent carboxylation and is thought to be related to bone mineralization. Gas6 is a vitamin K-dependent protein found throughout the nervous system, as well in the heart, lungs, stomach, kidneys and cartilage. Although the exact mechanism of its action has not been determined, Gas6 appears to be a cellular growth regulator involved in cellular activities such as cell adhesion, cell proliferation and protection against apoptosis.*

 

FAQ

 

Why is vitamin K included in Isotonix Vitamin D with K2? 
Vitamin K is included in this product because of its unique partnership with vitamin D. Vitamins K and D work together to promote healthy calcium absorption and utilization. Vitamin K supports the delivery of calcium to the bones and helps maintain arterial health.*

Is Isotonix Vitamin D with K2 safe for people on anti-coagulant medications? 
Some studies have concluded that vitamin K2 does not interfere with anticoagulant medications. However, most products containing vitamin K (including K1 and/or K2) warn users taking anticoagulants not to take the product. If you are currently taking warfarin or another anticoagulant medication, you should consult your physician before taking any product containing vitamin K1 or K2.

How do I take Isotonix Vitamin D with K2? 
Mix one capful of Isotonix Vitamin D with K2 with 2 ounces of water. Take one serving daily.

Is it safe to take more than one serving of this product daily? 
One serving daily of Isotonix Vitamin D with K2 is recommended. Check with your physician before taking additional daily servings of this product.

Is there a toxicity level for vitamin D? 
The recommended daily Upper Limit for vitamin D is 10,000 IU, however, safety studies indicate that up to 40,000 IU may be safe for most people. If you wish to take more than one daily serving of this product, you should check with your physician.

What are dietary sources of vitamin D? 
Foods rich in vitamin D include cod liver oil, salmon, mackerel and tuna.

 

Science

 

  • Knapen M et al. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporosis International. 18(7):963-72, 2007. 
  • Shiraki, M., et al. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. Journal of Bone & Mineral Research. 15:515-522, 2000.
  • Hiruma Y et al. Vitamin K(2) and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. Biochemical Biophysical Research Communications. 314(1):24-30, 2004.
  • Plaza S and La
  • Kameda T et al. Vitamin K2 inhibits osteoclastic bone resorption by inducing osteoclast apoptosis. Biochemical and Biophysical Research Communications. 220(3):515-519, 1996.
  • Taira H et al. Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. Calcified Tissue International. 73(1):78-85, 2003.
  • Hidaka T et al. Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2). Journal of Bone and Mineral Metabolism. 20(4):235-239, 2002.
  • Iwamoto J et al. Effects of vitamin K2 on osteoporosis. Current Pharmaceutical Design. 10(21):2557-2576, 2004.
  • Iwamoto J et al. Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. The Keio Journal of Medicine. 2003 Sep;52(3):147-50. Review. · Neogi, T., et al. Low vitamin K status is associated with osteoarthritis in the hand and knee. Arthritis and Rheumatism. 54(4):1255-1261, 2006.
  • Price P. Role of vitamin K-dependent proteins in bone metabolism. Annual Review of Nutrition. 8:565-583, 1988.
  • Bekner K. The vitamin K-dependent carboxylase. Journal of Nutrition. 130(8):1877-1880, 2000. 
  • Nelsestuen G et al. Vitamin K-dependent proteins. Vitamins and Hormones. 58:355-389, 2000.
  • Shearer M. Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Current Opinion in Clinical Nutrition and Metabolic Care. 3(6):433-438, 2000.
  • Gundberg C et al. Vitamin K status and bone health: an analysis of methods for determination under carboxylated osteocalcin. Journal of Clinical Endocrinology and Metabolism. 83(9):3258-3266, 1998.
  • Weber P. Management of osteoporosis: is there a role for vitamin K? International Journal for Vitamin and Nutrition Research. 67(5):350-6, 1997.
  • Garber, A. K., et al. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. Journal of Nutrition. 129(6):1201-1203, 1999.
  • Binkley N et al. Vitamin K nutrition and osteoporosis. Journal of Nutrition. 125(7):1812-1821, 1995.
  • Bischoff-Ferrari Het al. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 293(18):2257-2264, 2005.
  • Guirguis-Blake J et al. Oral vitamin D3 decreases fracture risk in the elderly. Journal of Family Practice. 52(6):431-435, 2003.
  • Schaafsma, A., et al. Vitamin D3 and vitamin K1 supplementation of Dutch postmenopausal women with normal and low bone mineral densities: effects on serum 25-hydroxyvitamin D and carboxylated osteocalcin. European Journal of Clinical Nutrition. 54:626-631, 2000.
  • Trivedi Det al. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. British Medical Journal. 326(7387):469, 2003.
  • Van den Berghe G et al. Bone turnover in prolonged critical illness: effect of vitamin D. Journal of Clinical Endocrinology and Metabolism. 88(10):4623-4632, 2003.
  • Chapuy M et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women. New England Journal of Medicine. 327(23):1637-1642, 1992.
  • Grant W and Holick M. Benefits and requirements of vitamin D for optimal health. Alternative Medicine Review. 10:94-111, 2005.
  • Plaza S and La
  • Zitterman A et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? Journal of the American College of Cardiology. 41(1):105-112, 2003.
  • Schleithoff S et al. Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. American Journal of Clinical Nutrition. 83(4):754-759, 2006.
  • Argiles A et al. Blood pressure is correlated with vitamin D(3) serum levels in dialysis patients. Blood Purification. 20(4):370-375, 2002.
  • Kristal-Boneh E et al. Association of calcitriol and blood pressure in normotensive men. Hypertension. 30(5):1289-1294, 1997.
  • Li Y et al. 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. Journal of Clinical Investigation. 110(2):229-238, 2002. 
  • Li Y et al. Vitamin D regulation of the renin-angiotensin system. Journal of Cell Biochemistry. 88(2):327-331, 2003.
  • Li Y et al. Vitamin D: a negative endocrine regulator of the renin-angiotensin system and blood pressure. Journal of Steroid Biochemistry and Molecular Biology. 89-90(1-5):387-392, 2004.
  • Pfeifer M et al. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. Journal of Clinical Endocrinology and Metabolism. 86(4):1633-1637, 2001.
  • Sigmund C. Regulation of renin expression and blood pressure by vitamin D(3). Journal of Clinical Investigation. 110(2):155-156, 2002.
  • Vasquez A et al. The clinical importance of vitamin D (cholecalciferol): a paradigm shift with implications for all healthcare providers. Alternative Therapies. 10(5):28-38, 2004.
  • Nimptsch K et al. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. American Journal of Clinical Nutrition. 87:985-992, 2008.
  • Habu D et al. Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver. JAMA. 292(3):358-361, 2004.
  • Yoshida T et al. Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer. International Journal of Oncology. 23(3):627-632, 2003.
  • La 
  • Yokoyama T et al. Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines. International Journal of Oncology. 26(1):33-40, 2005.
  • Chlebowski R et al. Vitamin K in the treatment of cancer. Cancer Treatment Review. 12:49-63, 1985.
  • La
  • Hitomi M et al. Antitumor effects of vitamins K1, K2 and K3 on hepatocellular carcinoma in vitro and in vivo. International Journal of Oncology. 26(3):713-720, 2005.
  • Nouso K et al. Regression of hepatocellular carcinoma during vitamin K administration. World Journal of Gastroenterology. 11(42):6722-6724, 2005.
  • Blackmore K et al. Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer.
  • American Journal of Epidemiology. 168(8):915-24, 2008. · Deluca H et al. Vitamin D: its role and uses in immunology. FASEB Journal. 15(14):2579-2585, 2001.
  • Adorini L. Immunomodulatory effects of vitamin D receptor ligands in autoimmune diseases. International Immunopharmacology. 2(7):1017-1028, 2002.
  • Cantorna M et al. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Experimental Biology and Medicine ( Maywood ). 229(11):1136-1142, 2004.
  • Cantorna M. Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence? Society for Experimental Biology and Medicine. 223:230-233, 2000.
  • Garland C et al. The role of vitamin D in cancer prevention. American Journal of Public Health. 96(2):252-61, 2006.
  • Giovannucci E et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. Journal of the National Cancer Institute. 98(7):451-459, 2006.
  • Holick, M. Vitamin D: Its role in cancer prevention and treatment. Progress in Biophysics and Molecular Biology. 92(1):49-59, 2006.
  • Gorham E et al. Vitamin D and prevention of colorectal cancer. Journal Steroid Biochemistry and Molecular Biology. 97(1-2):179-94, 2005.
  • Grant W et al. Reviews: A critical review of studies on vitamin D in relation to colorectal cancer. Nutrition and Cancer. 48(2):115-123, 2004.
  • Harris D et al. Vitamin D and colon carcinogenesis. Journal of Nutrition. 134(12):3463S-3471S, 2004. 
  • Hayes C et al. The immunological functions of the vitamin D endocrine system. Cellular and Molecular Biology. 49(2):277-300, 2003.

 

Maggie holds certifciations in the following areas:

Nutritional Studies & Applications, Alive Academy of Natural Health

Natural Health Fundamentals, Alive Academy of Natural Health

Vegetarian Nutrition, Alive Academy of Natural Health

Currently completing Nutrition for Sports & Exercise, Alive Academy of Natural Health

Certified Life Purpose Coach, The Life Purpose Institute

Advanced PSYCH-K 

Reconnective Healing Practitioner, Level I/II

Reconnective Healing Practitioner, Level III

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Isotonix Nutritionals Info

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What is Nutri-Physical® Nutritional Analysis?

Identifying areas of nutrition where you need extra supplementation is a difficult task. Harder still is wading through the vast assortment of vitamins and minerals that claim to improve your health and well-being. Maybe you have a rough idea of where to start, but why leave anything to chance?

That's why we developed Nutri-Physical Nutritional Analysis, a free tool that can help you chose the proper supplementation regimen based on your diet and lifestyle. The result of your Nutri-Physical are based on overall best fit derived from your answers to a detailed online questionnaire that takes into account diet and exercise, family history personal habits and more.

Unlike other health questionnaires, Nutri-Physical explores all aspects of your diet, lifestyle and fitness to make concrete recommendations. Plus, with a unique color coding system, you can easily identify which products are most important for your health.

Every three to four months, come back to Shop.com and retake Nutri-Physical to receive new supplement recommendations at no cost. It's easy, it's customizable and it's free - three great reasons to take your Nutri-Physical today!

How does Nutri-Physical work?

Nutri-Physical Nutritional Analysis was developed by a team of experts who designed a series of questions around major health-related conditions currently plaguing our nation. After taking the comprehensive questionnaire, your responses are analyzed, calculated, and ranked on a point system. Then, based on this analysis, a daily nutrition supplement regimen is suggested based on your area of highest need and which products best fit those needs.

You'll receive three options: one that includes individual supplement recommendations; a second that creates a personalized Nutri-Physical Custom Cocktail by Isotonix; and a third that includes both individual products and your Nutri-Physical Custom cocktail recommendation. You can decide to choose any of the three options, or customize your supplement order and purchase whatever products you choose.

What can Nutri-Physical do for me?

If you are new to supplementation, Nutri-Physical is an excellent resource for identifying areas of need in your current lifestyle that would benefit from nutritional supplementation. If you are already taking nutritional supplements, Nutri-Physical can serve to reinforce the use of those products or make recommended adjustments that would further optimize your efforts and maximize your desired results.

Nutri-Physical FAQ

Why should I take the Nutri-Physical?

Anyone who is looking to attain optimal health and vitality should take Nutri-Physical Nutritional Analysis. Learning about oneself is the key to maximizing these desired outcomes and Nutri-Physical does exactly that by utilizing your individual responses to specific health and lifestyle questions in several important categories.

How often should I take Nutri-Physical?

If one is looking seriously to obtain optimal health and vitality, taking the survey every 90 to 120 days should be sufficient.

What do I accomplish by taking Nutri-Physical every 90 to 120 days?

You will be able to track your improvements in deficiency percentages and make adjustments to your daily nutritional supplementation regimen.

What if I can not afford to implement the recommended nutritional supplementation regime?

First, look to evaluate each product recommended with its active ingredients and reference those active ingredients to food groups and specifically food types. Try to incorporate those foods into your daily diet.

Second, examine your commitment to reach optimal health and vitality, review your finances and become creative. Nutri-Physical lists its nutritional supplement recommendation according to your priorities determined from the product priorities which were based on your answers to the questions. Begin your program with one or two recommended products, if possible.

Should I consult my physician prior to starting a nutritional supplementation program?

Absolutely. Reaching optimal health and vitality means asking your health professional to identify any pre-existing conditions or to review the recommended nutritional supplements you wish to take and relate them to your current condition and any prescribed medication. Ask your Nutri-Physical Administrator for information on recommended nutritional products as well as the ingredients and nutritional facts. You can also click on the pictures of your recommended products for more information.

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